Parker's theater career continued when she appeared in Paula Vogel's 1997 critical smash How I Learned to Drive, with David Morse.In the late 1990s, she appeared in several independent films, including Let the Devil Wear Black and The Five Senses.
She starred alongside Sidney Poitier in the 1999 movie The Simple Life of Noah Dearborn.
On December 7, 2003, HBO aired a six-and-a-half-hour adaptation of Tony Kushner's acclaimed Broadway play Angels in America, directed by Mike Nichols.
Mary-Louise Parker (born August 2, 1964) is an American actress and author.
After making her stage debut as Rita in a Broadway production of Craig Lucas' Prelude to a Kiss in 1990 (for which she received a Tony Award nomination), Parker came to prominence for film roles in Grand Canyon (1991), Fried Green Tomatoes (1991), The Client (1994), Bullets over Broadway (1994), Boys on the Side (1995), The Portrait of a Lady (1996), and The Maker (1997).
After receiving both Golden Globe and Primetime Emmy Awards for her portrayal of Harper Pitt on the HBO television miniseries Angels in America in 2003, Parker went on to enjoy large success as Nancy Botwin, the lead role on the Showtime television series Weeds, which ran from 2005 to 2012 and for which she received three nominations for the Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series between 20 and received the Golden Globe Award for Best Actress – Television Series Musical or Comedy in 2006. Since 2007, Parker has contributed articles for Esquire magazine and later published her memoir, Dear Mr. In 2017, she starred as Roma Guy on the ABC television miniseries When We Rise.