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The end of menses is due in part to estrogen levels that are too low to stimulate the lining of the uterus (endometrium).

In addition to the end of menses, significant estrogen loss can also lead to: Estrogen products may provide either a single type of estrogen or mixed estrogens.

Oral estrogens seem to have more side effects than estrogens delivered through the skin or the vagina, apparently due to the "first pass" through the liver that occurs when drugs are taken by mouth.

Results of a study reported in the Journal of the American College of Cardiology (April 2003) show that Premarin pills, a form of oral estrogen, increase C-reactive protein (CRP) in the blood, while Climara, an estrogen skin patch, does not.

CRP is a marker of inflammation in the blood that has been found to be a heart disease risk factor.

Whether from your own ovaries or from an external source, estrogens work in the body by traveling in the blood to body tissues where there are estrogen receptors.

Estrogen receptors are found in the brain, breasts, heart, blood vessels, uterus, vagina, bladder, liver, bones, skin, and gastrointestinal tract.

In addition, the ovaries continue making small amounts of testosterone, which can be converted to estradiol.

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